This workshop in applied pharmacokinetics is organized by ADCAPT (Hospices Civils de Lyon) and the Laboratory of Applied Pharmacokinetics of the University of Southern California School of Medicine. It is designed for clinicians, practitioners, and those in the industry who are interested in the need to manage, control, and minimize the variability of various potentially toxic drugs and medications. This work utilizes the work, concepts, and both the clinical and research software developed jointly by ADCAPT since 1986 and by USC since 1967.

• Hospices Civils de Lyon,
• University of Southern California (Los Angeles),
• CNRS - GdR Automatique,
• Université Claude Bernard - Lyon I,
• European Society of Clinical Pharmacology.

While techniques of modeling drug behavior using population pharmacokinetic/dynamic models have evolved considerably during the past 30 years, their clinical applications have not kept pace. The initial interest in reducing toxicity, for example, with antibiotics, has diminished, and the use of these techniques in new areas has not been optimized (for example, in AIDS and cancer chemotherapy, antihemophilic therapy, reduction of the secondary effects of anticoagulants and psychotropic drugs, and in transplant management). Similarly, the legal descriptions of medications already commercialized has grown, notably concerning populations at risk, in whom the variability has become better known, but the by now well-established techniques for managing such risks optimally with digoxin, lidocaine, aminoglycosides, and, more recently, busulfan, have not always been recommended and employed in new situations. This workshop seeks to remedy this problem.

An initial day of conferences and discussions, on Wednesday June 27, followed, for those who wish it, by a second day of practical applications, done in small group discussions in a clinical setting. Thursday June 28 will be primarily for those participants from outside Lyon, while Friday June 29 will be primarily for those from the area of Lyon and its environs.

It is preferable, but not indispensable, that the participants have some prior experience in the use of software for dosage adaptation and adjustment, and for population PK/PD modeling.

The official languages will be French and English. Simultaneous translation will not be provided, but may be possible to facilitate small group discussions as needed.

The number of participants is limited to 100 on the first day, and to 20 on the second and third days. Because of this, registrations will be given in the order received.

The first day of conferences and discussions will take place in the Grand Réfectoire des Sœurs de l'Hôtel Dieu (Hospices Civils de Lyon).

The second and third days of practical and directed will be held at the Pharmacy Service, Hospital Antoine Charial (Hospices Civils de Lyon).

L'Hôtel Dieu and the Hospital Antoine Charial are easily reached: The Hôtel Dieu is in central Lyon. The Hospital Antoine Charial is reached from the center of Lyon by the metro, line D, direction Gare de Vaise, station Gorge de Loup) then by bus (n°74, station Maison de Santé / Hospital A. Charial).

Lyon, noted for its historic center (inscribed in the World Inheritance of UNESCO), is an ideal place for convivial gatherings of this type. It is easily reached by plane (Aéroport International Saint Exupéry), by train (TGV) and by various highways (A6, A7, A42,…).

A fee of 100 Euros (655 FF) for the first day (Tuesday June 26 only), 200 Euros (1310 FF) for the two days (Wednesday the 27^th and Thursday the 28^th and for those outside the Lyon area or Wednesday the 27^th and Friday the 29^th for those from Lyon). This includes the proceedings and work notes, and for the second day (the 28^th or 29^th) the noon lunch at Hospital A. Charial; it does not include the lunch on Wednesday the 29^th, as many restaurants are available nearby. It also does not include any hotel expenses.

A convivial get-together will be planned at the Hôtel Dieu if enough registrants indicate that they would like it.

Lodging is not included in the registration fee. Registrants will receive a list of hotels nearby, and a map.

• Roger W. Jelliffe, M.D., is Professor of Medicine at the USC School of Medicine, and Director of its Laboratory of Applied Pharmacokinetics. He is at the forefront of adaptive control of drug dosage. With his colleagues and students, he has published many important contributions to pharmacokinetics over more than thirty years.
• Pascal Maire, Ph.D., is Chief Pharmacist at the Hospital Antoine Charial, Hospices Civils de Lyon. He has studied, in particular, the problems of differential aging with respect to renal function, and the practical methods of dosage adjustment in clinical practice, with his successive courses of interns, DEA colleagues. He has been the origin of ADCAPT and has been its guiding spirit for the last fifteen years.
• Daniel Claude, Ph.D., is Professor of Mathématics at Université d'Orsay (Paris XI) and director of the program "Automatique et Biologie" of GdR CNRS "Automatique".
• Xavier Barbaut, Pharm.D., is Hospital Pharmacist in Centre Hospitalier de Beaune. He has played a leading role in developing the pharmacodynamic sub-routines in the USC*Pack programs. He is currently président of ADCAPT.
• Nils Ove Hoem, Ph.D., M.Sc (Pharm), is Associate Professor of Pharmacology, School of Pharmacy, University of Oslo, Norway.
• Irina Bondareva, Ph.D., is a mathématician at the Institute for Physical and Chemical Medicine, Moscow, Russia.
• Michel Maurin, Ph.D., is a mathematician at INRETS (Institut National de Recherche sur les Transports et leur Sécurité).
• Nathalie Bleyzac, Pharm.D., Ph.D., is Assistant Spécialiste at the pediatric Hospital Debrousse (Hospices Civils de Lyon).
• Michel Ducher, Pharm.D., Ph.D., is Attaché at the geriatric Hospital A. Charial (Hospices Civils de Lyon).
• Jean-Maurice Vergnaud, Ph.D., is Honorary Professor of Chemistry and Materials at the Faculté of Sciences in Saint Etienne.
• Bruno Charpiat, Pharm.D., is a Hospital Pharmacist in Hospices Civils de Lyon (Hôpital de la Croix Rousse).
• Valérie Chamouard, Pharm.D., is a Hospital Pharmacist in Hospices Civils de Lyon (Hôpital Edouard Herriot).
• Stéphane Corvaisier is Assistant Spécialiste at Hôpital Neuro-Cardiologique (Hospices Civils de Lyon).
• Florent Rougier (HCL), Nathalie Choudey (AP Paris) and Frédéric Foltz (HCL) are residents in Pharmacy.
• On the second and third days, certain colleagues of ADCAPT will be particularly devoted to its various activities : Cécile Baumgartner, Xavier Barbaut, Nathalie Bleyzac, Michel Bouvier d'Yvoire, Gérard Carret, Valérie Chamouard, Pascal Chanu, Bruno Charpiat, Nathalie Choudey, Daniel Claude, Marie-Aude Confesson, Stéphane Corvaisier, Christian Cote, Michel Druguet, Michel Ducher, Marie-Stéphane Essner, Frédéric Foltz, Rémi Gauchoux, Anne-Maelle Guignon, Alain Laffont, Nicolas Laurent, Stéphane Lecoq, Patrice Martin, Michel Maurin, Annick Patoux, Christine Pivot-Dumarest, Florent Rougier, Fabienne Vial, Jean-Maurice Vergnaud, et al.

Gilles Aulagner, Xavier Barbaut, Nathalie Bleyzac, Gérard Carret, Bruno Charpiat, Daniel Claude, Marie-Aude Confesson, Stéphane Corvaisier, Serge Ferry, Roger W. Jelliffe, Stéphane Lecoq, Pascal Maire, Christine Pivot, Jean Sassard.

Joëlle Baffie, ADCAPT – Pharmacy Service, Hospital A. Charial, 40 avenue de la Table de Pierre, 69340 Francheville, France ; tél : (33) 04 72 32 34 87, fax : (33) 04 72 32 39 08, email : adcapt@cismsun.univ-lyon1.fr

International Secrétariat : Michel Ducher, Hôpital A. Charial, 40 avenue de la Table de Pierre, 69340 Francheville, France ; tél : (33) 04 72 32 34 87, fax : (33) 04 72 32 39 08, email : adminstrateur@mduch.org

• Hospices Civils de Lyon,
• CNRS - GdR Automatique,
• Division of Geriatric Medicine, University of Southern California (Los Angeles),
• Université Claude Bernard - Lyon I,
• European Society of Clinical Pharmacology,
• Ville de Lyon,
• Assistance Transit Melody,

Dr. Pascal Maire, Pr. Roger W. Jelliffe,

Dr. Pascal Maire,

Description of therapeutic variability by population PK/PD modeling in 2001,

Pr. Roger W. Jelliffe,

The Hill's equation revisited, Dr. Michel Maurin,

Dr. Nils Ove Hoem,

Modeling the differential renal aging process - an example of the Z coefficient

with amikacin, - Dr. Michel Ducher,

Modeling the toxicity of drugs - example with renal toxicity of aminoglycosides,

Dr. Florent Rougier,

Dr. Irina Bondareva,

All participants,

Pr. Roger W. Jelliffe,

Dr. Xavier Barbaut,

Pr. Daniel Claude,

Pr. Jean-Maurice Vergnaud,

Drs. Bruno Charpiat, et aL

Dr . Nathalie Bleyzac,

Drs. Valérie Chamouard, Marie-Stéphane Essner, et al.

Dr. Nathalie Choudey,

All participants.

Pr. Roger W. Jelliffe, Dr. Pascal Maire, and ADCAPT,

Pr. Roger W. Jelliffe,

Dosage adaptation in practice, using Win USC*Pack ,

Members of ADCAPT,

Pr. Roger W. Jelliffe,

Population modeling with NPEM : practical examples,

Members of ADCAPT

Pr. Roger W. Jelliffe, Dr. Pascal Maire, and ADCAPT,

Pr. Roger W. Jelliffe,

Dosage adaptation in practice, using Win USC*Pack ,

Members of ADCAPT,

Pr. Roger W. Jelliffe,

Population modeling with NPEM : practical examples,

Members of ADCAPT