Workshop: Jan 9, 2001

An evening workshop on Current Issues in Pharmacometrics: Optimal Modeling and Therapy.

The workshop takes place on Tuesday, January 9 2001 from 07:00-10:00 PM (time is tentative), during the Western Multiconference 2001 (International Conference on Health Sciences Simulation) at the Crowne Plaza Hotel, Phoenix AZ, January 7-11, 2001.

This workshop is designed for physicians, pharmacists, and scientists interested in studying the behavior of drugs in patients and animals, and in applying that information to regulatory agencies and to optimal patient care. A basic, but not an advanced, knowledge of pharmacokinetics, experimental design, and therapeutic drug monitoring will be useful.

Faculty: Roger Jelliffe, M.D. - USC Keck School of Medicine. LA
         Nils O. Hoem, Ph. D - School of Pharmacy, University of Oslo, Norway

The following issues to start the discussion are proposed:

7:00    Introduction
             "Why Pharmacometrics anyway?"
             "Why Clinical Pharmacokinetics?"
             Management of Data - Poor and Uncertain Clinical situations.
             "Decision support" and "Control of PK/PD systems".
7:20    Population Modeling
             Why? What will be done with the model? How?
7:40    The Separation Principle and the Advantages of Non-Parametric methods
8:00    Optimal Procedures for Population Modeling
             Separation of Assay error from other sources of variability 
             IT2B or Parametric approach then Nonparametric
             Model parameterization and covariates
8:30    New tools for making large non-linear models: Big-IT2B and Big-NPEM 
             Easy, Web based access to either a cluster or a supercomputer
             Adding effect models, multiple drug combinations, interactions.
9:00    Linking of NPEM models to Multiple Model Adaptive Dosage Design
           - The Clinical Application
9:15    Multiple Model Dosage Design for maximally precise Drug Therapy.
             "Goal-Oriented, Optimal Dosing" ("GOOD") Drug Therapy
             New Bayesian tracking of Drug behavior in unstable patients.
9:45	Concluding remarks and discussion
10:00	Adjourn