Representative technical reports

 
  Clinical Applications

 TR-97-1. R. Jelliffe
Goal-Oriented, Model-Based Drug Regimens: Setting Individualized Goals for Each Patient. [ .pdf ]
TR-97-3. R. Jelliffe
Estimation of Creatinine Clearance in Patients with Unstable Renal Function. [ .pdf ]
TR-97-4. R. Jelliffe
Achieving Concentration Goals using Parametric Compartmental Models - The Current Unimodal Gaussian Bayesian Approach. [ .pdf ]
TR-97-5. R. Jelliffe, X. Barbaut, P. Maire, A. El Brouzi, and J.M. Vergnaud
Analyzing Concentrations in Spherical Diffusion Models: Analysis Of Endocardial Vegetations and of Post-Antibiotic Effect. [ .pdf ]
TR-97-6. R. Jelliffe, P. Maire, and X. Barbaut
Modeling Organism Growth and Kill: Clinical Applications. [ .pdf ]
TR-97-7. R. Jelliffe
Initial Conditions and their Use in Therapeutics: an Aminoglycoside and a Digoxin Patient with Rapid Changes in Model Parameter Values. [ .pdf ]
TR-97-8. R. Jelliffe, D. Bayard, M. Milman, M. Van Guilder, and A. Schumitzky
Achieving Concentration Goals with Nonparametric Compartmental Models - the "Multiple Model" Design of Dosage Regimens. [ .pdf ]
TR-94-1. R. Jelliffe, A. Schumitzky, D. Bayard, M. Milman, P. Maire, X. Barbaut, A. Hurst, B. Charpiat, V. Breant, C. Pivot-Dumarest, and B. Tahani
Adaptive Control of Drug Dosage Regimens: An Overview of Basic Concepts, Relevant Issues, and Some Clinical Applications. [ .pdf ]
TR-94-2. D.S. Bayard, R.W. Jelliffe, A. Schumitzky, M.H. Milman, and M. Van Guilder
Precision Drug Dosage Regimens Using Multiple Model Adaptive Control: Theory, and Application to Simulated Vancomycin Therapy.
TR-93-1. B. Charpiat, V. Breant, C. Dumarest, P. Maire, and R. Jelliffe
Prediction of Future Serum Concentrations with Bayesian Fitted Pharmacokinetic Models: Results with Data Collected by Nurses versus Trained Pharmacy Residents. [ .pdf ]
TR-92-2. R. W. Jelliffe, F.Sattler, P. Gomis, and B. Tahani
Adaptive Control of Drug Dosage Regimens: Basic Foundations, Relevant Issues, and Clinical Examples. [ .pdf ]
TR-92-5. R. W. Jelliffe, and B. Tahani
A Library of Serum Drug Assay Error Patterns, and Some Suggestions for Improved Modeling and Simulation of Pharmacokinetic Behavior. [ .pdf ]
TR-90-3. R.W. Jelliffe, A. Schumitzky, and M. Van Guilder
A Simulation Study of Factors Affecting Aminoglycoside Therapeutic Precision.

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  Pharmacokinetics and PK/PD Population Modeling

TR-2000-1. D. Bayard and R. Jelliffe
Bayesian Estimation of Posterior Densities for Pharmacokinetic Models having Changing Parameter Values. [ .pdf ]
TR-99-1. R. Jelliffe, M. Van Guilder, R. Leary, A. Schumitzky, X. Wang, and A. Vinks
Nonlinear Parametric and Nonparametric Population Pharmacokinetic Modeling on a Supercomputer. [ .pdf ]
TR-97-2. R. Jelliffe and B. Tahani
Fitting the Data According to its Credibility: Determining the Assay Error Pattern. [ .pdf ]
TR-94-3. A. Schumitzky
EM Algorithms and Two Stage Methods in Pharmacokinetic Population Analysis.
TR-93-2. R. Jelliffe
Effect of Assumptions concerning Assay Error Patterns upon Pharmacokinetic Parameter Values and Model Behavior. [ .pdf ]
TR-90-2. A. Schumitzky
Nonparametric EM Algorithms for Estimating Prior Distributions. [ .pdf ]
TR-90-4. R. W. Jelliffe, P. Gomis, and A. Schumitzky
A Population Model of Gentamicin Made With a New Nonparametric EM Algorithm. [ .pdf ]

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  Computational Mathematics

TR-98-1. M. Milman, F. Jiang, R. Jelliffe, and X. Wang
Monment Matching/Maximun Entropy Optimization. [ .pdf ]
TR-98-2. D. S. Bayard and A. Schumitzky
Stochastic Optimal Experiment Design. [ .pdf ]
TR-97-10. X. Wang, M. Milman, and F. Jiang
On-the-Fly Generations of the Constraint Matrix in a Maximum Entropy Problem. [ .pdf ]
TR-97-9. X. Wang
Scalable Parallel Matrix Multiplication Algorithms with Application to a Maximum Entropy Problem. [ .pdf ]
TR-91-1. A. Schumitzky
Application of Stochastic Control Theory to Optimal Design of Dosage Regimens. [ .pdf ]

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