Laboratory of Applied Pharmacokinetics and Bioinformatics Optimizing drug therapy for populations and individuals |

- TR-2014-1:
*W. Yamada, J. Bartroff, D. Bayard, J. Burke, M. Van Guilder, R. Jelliffe, R. Leary, M. Neely, A. Kryschenko, A. Schumitzky*. "The Nonparametric Adaptive Grid Algorithm for Population Pharmacokinetic Modeling" - TR-2012-2:
*R. Jelliffe*. "Digoxin and Digitoxin Convert Atrial Fibrillation and Flutter to Regular Sinus Rhythm with Pharmacokinetically Optimized Dosage Regimens" - TR-2012-1:
*R. Jelliffe, L. Bechtol, R. Crabtree*. "The bioavailability and pharmacokinetic behaviour of digitoxin" - TR-2011-2:
*R. Jelliffe*. "Some Comments and Suggestions concerning Population Pharmacokinetic Modeling, especially of Digoxin, Monitoring its Therapy with Serum Concentrations, and Optimizing its Clinical Dosage Regimens" - TR-2011-1:
*R. Jelliffe, D. Bayard, R. Leary, A. Schumitzky, M. Van Guilder, A. Botnen, A. Bustad, M. Neely*. "A Hybrid Bayesian method to obtain Bayesian Posterior Parameter Distributions in Nonparametric Pharmacokinetic Models for Individual Patients" - TR-2009-1:
*R. Jelliffe, A. Schumitzky, D. Bayard, R. Leary, A. Botnen, M. Van Guilder, A. Bustad, M. Neely*. "Human Genetic Variation, Population Pharmacokinetic - Dynamic Models, Bayesian Feedback Control, and Maximally Precise Individualized Drug Dosage Regimens" - TR-2000-1:
*D. Bayard and R. Jelliffe*. "Bayesian Estimation of Posterior Densities for Pharmacokinetic Models having Changing Parameter Values" - TR-1999-1:
*R. Jelliffe, M. Van Guilder, R. Leary, A. Schumitzky, X. Wang, and A. Vinks*. "Nonlinear Parametric and Nonparametric Population Pharmacokinetic Modeling on a Supercomputer" - TR-1998-2:
*D. S. Bayard and A. Schumitzky*. "Stochastic Optimal Experiment Design" - TR-1998-1:
*M. Milman, F. Jiang, R. Jelliffe, and X. Wang*. "Monment Matching/Maximun Entropy Optimization" - TR-1997-9:
*X. Wang*. "Scalable Parallel Matrix Multiplication Algorithms with Application to a Maximum Entropy Problem" - TR-1997-8:
*R. Jelliffe, D. Bayard, M. Milman, M. Van Guilder, and A. Schumitzky*. "Achieving Concentration Goals with Nonparametric Compartmental Models - the Multiple Model Design of Dosage Regimens" - TR-1997-7:
*R. Jelliffe*. "Initial Conditions and their Use in Therapeutics: an Aminoglycoside and a Digoxin Patient with Rapid Changes in Model Parameter Values" - TR-1997-6:
*R. Jelliffe, P. Maire, and X. Barbaut*. "Modeling Organism Growth and Kill: Clinical Applications" - TR-1997-5:
*R. Jelliffe, X. Barbaut, P. Maire, A. El Brouzi, and J.M. Vergnaud*. "Analyzing Concentrations in Spherical Diffusion Models: Analysis Of Endocardial Vegetations and of Post-Antibiotic Effect" - TR-1997-4:
*R. Jelliffe*. "Achieving Concentration Goals using Parametric Compartmental Models - The Current Unimodal Gaussian Bayesian Approach" - TR-1997-3:
*R. Jelliffe*. "Estimation of Creatinine Clearance in Patients with Unstable Renal Function" - TR-1997-2:
*R. Jelliffe and B. Tahani*. " Fitting the Data According to its Credibility: Determining the Assay Error Pattern" - TR-1997-10:
*X. Wang, M. Milman, and F. Jiang*. "On-the-Fly Generations of the Constraint Matrix in a Maximum Entropy Problem" - TR-1997-1:
*R. Jelliffe*. "Goal-Oriented, Model-Based Drug Regimens: Setting Individualized Goals for Each Patient" - TR-1994-3:
*A. Schumitzky*. " EM Algorithms and Two Stage Methods in Pharmacokinetic Population Analysis" - TR-1994-2:
*D.S. Bayard, R.W. Jelliffe, A. Schumitzky, M.H. Milman, and M. Van Guilder*. "Precision Drug Dosage Regimens Using Multiple Model Adaptive Control: Theory, and Application to Simulated Vancomycin Therapy" - TR-1994-1:
*R. Jelliffe, A. Schumitzky, D. Bayard, M. Milman, P. Maire, X. Barbaut, A. Hurst, B. Charpiat, V. Breant, C. Pivot-Dumarest, and B. Tahani*. "Adaptive Control of Drug Dosage Regimens: An Overview of Basic Concepts, Relevant Issues, and Some Clinical Applications" - TR-1993-2:
*R. Jelliffe*. " Effect of Assumptions concerning Assay Error Patterns upon Pharmacokinetic Parameter Values and Model Behavior" - TR-1993-1:
*B. Charpiat, V. Breant, C. Dumarest, P. Maire, and R. Jelliffe*. "Prediction of Future Serum Concentrations with Bayesian Fitted Pharmacokinetic Models: Results with Data Collected by Nurses versus Trained Pharmacy Residents" - TR-1992-5:
*R. Jelliffe, and B. Tahani*. "A Library of Serum Drug Assay Error Patterns, and Some Suggestions for Improved Modeling and Simulation of Pharmacokinetic Behavior" - TR-1992-2:
*R. Jelliffe, F.Sattler, P. Gomis, and B. Tahani*. "Adaptive Control of Drug Dosage Regimens: Basic Foundations, Relevant Issues, and Clinical Examples" - TR-1991-1:
*A. Schumitzky*. "Application of Stochastic Control Theory to Optimal Design of Dosage Regimens" - TR-1990-4:
*R. Jelliffe, P. Gomis, and A. Schumitzky*. " A Population Model of Gentamicin Made With a New Nonparametric EM Algorithm" - TR-1990-3:
*R.W. Jelliffe, A. Schumitzky, and M. Van Guilder*. "A Simulation Study of Factors Affecting Aminoglycoside Therapeutic Precision" - TR-1990-2:
*A. Schumitzky*. " Nonparametric EM Algorithms for Estimating Prior Distributions"