Laboratory of Applied Pharmacokinetics and Bioinformatics
Optimizing drug therapy for populations and individuals


The USC Laboratory of Applied Pharmacokinetics (LAPK) of the Keck School of Medicine at the University of Southern California is a pharmacometric resource for optimal study and control of pharmacokinetic/pharmacodynamic systems and for individualized drug therapy and personalized medicine. It is supported by grants from The National Institute for General Medical Studies (GM068968), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD070996).

Established in 1973, LAPK continues to develop improved methods for the optimal study and control of pharmacokinetic systems. These methods are designed for optimal analysis of drug behavior and optimal care of patients through optimal stochastic control of their drug therapy. In addition to current funding, the laboratory has been supported in the past by NIH grant EB005803 and by the Stella Slutzky Kunin Memorial Research Fund.

The laboratory is concerned with mathematical and statistical modeling of drug behavior, as well as with clinical testing and evaluation of new methods for optimizing drug therapy. The core of this multidisciplinary activity contains physicians, pharmacists, engineers, statisticians, and mathematicians. The laboratory has special strengths in optimal stochastic control, optimal design of pharmacokinetic experiments and clinical trials, and with their practical application of tools for optimal clinical therapy.

The laboratory also seeks collaborative relationships to further the understanding and development of this field of Clinical Pharmacology. These collaborations may take the form of clinical trials and evaluations of therapeutic methods or of development and software implementation of new concepts. Educational opportunities in the form of workshops and Fellowships are available to physicians, pharmacists, engineers, mathematicians, and other investigators. Fellowship applications in Clinical Pharmacology and Clinical Pharmacy are encouraged.