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Laboratory of Applied Pharmacokinetics and Bioinformatics Optimizing drug therapy for populations and individuals |
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Laboratory of Applied Pharmacokinetics and Bioinformatics Optimizing drug therapy for populations and individuals |
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Below are template models that can be used and modified in Pmetrics.
If you'd like to contribute additional models, please contact us!
You can learn about the model format here.
The templates below contain generic values for parameter ranges and the error block.
You should replace them as appropriate, although they may be good starting values if you have no other information
about your model parameter values.
| Model | Compartments | Inputs | Parameters | Outputs | Download |
|---|---|---|---|---|---|
 |
1 | RATEIV(1) | V, Volume of compartment 1 Ke, Elimination from compartment 1 |
Y(1) | Model file (algebraic) |
 |
2 | NBOLUS(1) RATEIV(1) |
Ka, Absorption from compartment 1 to 2 V, Volume of compartment 2 Ke, Elimination from compartment 2 |
Y(1) | Model file (algebraic) Model file (ODE) |
 |
2 | NBOLUS(1) RATEIV(1) |
Tlag(1), Time lag for absorption of input 1 Ka, Absorption from compartment 1 to 2 V, Volume of compartment 2 Ke, Elimination from compartment 2 |
Y(1) | Model file (algebraic) |
 |
2 | NBOLUS(1) RATEIV(1) |
FA(1), Bioavailability of input 1 Ka, Absorption from compartment 1 to 2 V, Volume of compartment 2 Ke, Elimination from compartment 2 |
Y(1) | Model file (algebraic) |
 |
2 | NBOLUS(1) RATEIV(1) |
X(2), Initial amount in compartment 2 Ka, Absorption from compartment 1 to 2 V, Volume of compartment 2 Ke, Elimination from compartment 2 |
Y(1) | Model file (algebraic) |
 |
2 | NBOLUS(1) RATEIV(1) |
Ka, Absorption from compartment 1 to 2 V, Volume of compartment 2 MM, Michaelis-Menten elimination from compartment 2 |
Y(1) | Model file (ODE) |
 |
3 | NBOLUS(1) RATEIV(1) |
Ka, Absorption from compartment 1 to 2 V, Volume of compartment 2 KCP, Transfer rate constant from compartment 2 to 3 KPC, Transfer rate constant from compartment 3 to 2 Ke, Elimination from compartment 2 |
Y(1) | Model file (algebraic) Model file (ODE) |
 |
3 | NBOLUS(1) RATEIV(1) |
Ka, Absorption from compartment 1 to 2 Vc, Volume of compartment 2 Q, Intercompartmental clearance between compartment 2 and 3 Vp, Volume of compartment 3 CL, Clearance from compartment 2 |
Y(1) | Model file (algebraic) Model file (ODE) |
 |
3 | NBOLUS(1) RATEIV(1) |
Ka, Absorption from compartment 1 to 2 V2, Volume of compartment 2 K20, Total elimination of parent from compartment 2 V3/fm, Volume of compartment 3 over fraction of parent metabolized K30, Elimination of metabolite from compartment 3 |
Y(1) Y(2) |
Model file (ODE) |